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KMID : 0363620060270020211
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Journal of Korean Oriental Medicine
2006 Volume.27 No. 2 p.211 ~ p.224
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Effects of Pinelliae Rhizoma on Obese Zucker Rats’ Blood Serum Lipids and Skeletal Muscles Fatty Acid Metabolism
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Yun Sang-Gu
Kim Ho-Jun
Lee Myeong-Jong
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Abstract
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Objectives :This study was performed to investigate the effects of Pinelliae rhizoma on blood serum lipids and skeletal muscle fatty acid metabolism of obese Zucker rats.
Methods :Experimental groups were divided into normal Zucker rats (lean control; non-treated), obese Zucker rats (fat control; non-treated) and Pinelliae rhizoma oral feeding obese Zucker rats (fat control; treated) for 6 separate experiments. Pinelliae rhizoma was investigated for effects on total body weight, serum glucose content, total cholesterol and triglyceride content, free fatty acid content, PPARalpha, CS and beta-HAD.
Results :1. Triglycerides in blood serum showed a greater decrease in the Pinellia rhizoma oral feeding group than the overweight control group. 2. PPARa showed a significant increase in the Pinelliae rhizoma oral feeding group over the overweight control group in skeletal muscles of SOL and EDL: as for protein FABPc, the Pinelliae rhizomaoral feeding group saw a greater significant increase than the overweight control group in the skeletal muscles of SOL. 3. CS activity showed a greater increase for the Pinelliae rhizoma oral feeding group than the overweight control group in EDL
Conclusions :As the experiment’’s results show, Pinelliae rhizoma effectively decreased the weight and triglycerides of the obese mouse, and somewhat affects the fat oxidation in the skeletal muscles.
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KEYWORD
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Pinelliae rhizome, fatty acid metabolism, obese Zucker rats, PPARalpha, citrate synthase, beta-HAD
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